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Theme: The interaction of bone with other organ systems

Saturday, 2 August

Sunday, 3 August

• Introduction (Paul Baldock, Garvin Institute of Medical Research)
• The role of the Sympathetic Nervous System in control of bone homeostasis (Florent Eleftheriou, Vanderbilt University)
• Osteoblastic Neuropeptide Y signaling and the control of bone homeostasis (Ivo Kalajzic, Univ of Connecticut)
• Selective inhibition of AP-1 in AgRP/NPY or CART/POMC, but not SF1, hypothalamic neurons simultaneously increases energy expenditure and bone density in mice (Anna Idelevich, Harvard University)
• The skeletal response to chronic obesity: Central neuropeptide responses to long term leptin over exposure (Paul Baldock, Garvan Institute of Medical Research) 
• Leptin stimulates bone formation at very low circulating levels of the hormone (Russell Turner, Oregon State University) 
• Reduction in Proximal Tibia Compartmental Bone Mineral as a Function of Time since Spinal Cord Injury (Brent Edwards, University of Calgary, Harold M. Frost award winner) 

Monday, 4 August

• Association between bone fragility and vascular calcification – evidence from epidemiological studies (Pawel Szulc, INSERM, France)
• Biological mechanisms underlying the association between vascular and bone metabolism (Dwight Towler, Diabetes and Obesity Research Center, Sanford Burnham)
• Role of matrix vesicles in the pathogenesis of cardiovascular calcification (Elena Aikawa, Brigham and Women's Hospital)
• Role of the oxidized lipids as factors underlying the association between bone fragility and vascular calcification (Yin Tintut, UCLA) 

How do I put together a curriculum vitae?

(a)  Overview of CV examples

(b)  Breakout sessions with mentors reviewing each young investigator’s CV

The Interview Process: A panel discussion centered around interviewing for positions at different levels: postdoctoral, faculty, industry.  Panel members will include a member of a current search committee in an academic department; an industry scientist with experience in hiring; a basic and a clinical scientist working within a clinical department; a departmental chair

Tuesday, 5 August

• An Overview of Muscle Mechanics and Biology (Richard Lieber, UCSD)
• How Changes in the Muscle Clock Genes can cause Osteoarthritis in Mouse Models (Karyn Esser, University of Kentucky)
• Nutrient Regulation of the Muscle-Bone Axis (Mark Hamrick, Georgia Health Sciences Institute)
• Bone-Muscle-Fat Interactions and the Association with Fractures and Frailty (Andy Kin On Wong, McMaster University) 
• Deletion of Connexin43 in osteoblasts/osteocytes leads to impaired muscle formation and performance (Hua Shen, Washington University in St. Louis, Alice L. Jee award winner) 

Wednesday, 6 August

• T cells: Unexpected players in the mechanism of action of PTH in bone and hemopoietic systems (Roberto Pacifici, Emory University)
• Inflammation and Bone (Mary Nakamura, UCSF)
• The bone disease of HIV and antiretroviral therapy (Neale Weitzmann, Emory University)
• T cells and bone metastisis (Roberta Faccio, Washington University)
• Evolutionary medicine and bone loss in chronic inflammatory diseases - a theory of inflammation-related osteopenia (Rainer Straub, University Hospital Regensburg) 
• Genome-wide DNA methylation study identifies significant epigenomic changes in osteoarthritic cartilage (Matlock Jeffries, University of Oklahoma Health Sciences Center) 

• Gut-Bone signaling overview (Laura McCabe, Michigan State University)
• Prebiotics, microbiota and bone health (Connie Weaver, Purdue University)
• Gut inflammation, probiotics and bone health (Laura McCabe, Michigan State University
• Gut microbiota modulate bone density (Claes Ohlsson, University of Gothenburg)
• Nod1 and Nod2 signalling mediates the effect of the gut microbiota on cortical bone mass (Klara Sjogren, University of Gothenburg)