This is a tentative program. Check back often for more details...
Sunday, August 1, 2010 AM: Issues in Modern Histomorphometry – 50 Years Later
(Co-Chairs: R. Recker, Creighton University and D. Dempster, Helen Hayes Hospital/Columbia University)
- Overview of Issues (R. Recker, Creighton University)
- Histomorphometry in translational research (D. Kimmel, Merck and Co.)
- Remodeling oversuppression and the handling of missing and single labels (D. Dempster, Helen Hayes Hospital)
- The meaning and measurement of activation frequency and erosion depth (R. Weinstein, University of Arkansas)
- Panel Discussion: (Drs. Recker, Dempster, Wronski, Weinstein, and Kimmel)
Sunday Afternoon (2:00pm - 4:00pm)
Volleyball at Sun Valley Lake! Refreshments provided!
This is a great place to get acquainted with other participants on a very informal basis. Even if you don't play volleyball, stop by for some refreshments and conversation. EVERYONE WELCOME!
Sunday PM: The RIB Award/Plenary Lecture
Osteocytes and Bone Remodeling: They’re Dying To Do the Job (Mitchell Schaffler, CUNY)
Monday AM: Tendons: The Connection Between Bone and Muscle
(Chair: J. Hannafin)
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Overview (J. Hannafin, Hospital for Special Surgery)
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Insights into clinical and biological aspects of tendon biology, mechanics and repair (J. Hannafin, HSS)
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Molecular differentiation of tendons: scleraxis and Mohawk transcription factors (R. Schweitzer, University of Oregon)
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Biological and molecular approaches to enhance healing and repair of tendons (D. Kaplan,Tufts University)
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Rabbit Tendon Stem Cells for Repair and Regeneration (J. Wang, University of Pittsburgh)
Monday PM 1:30-4:40PM: Workshop on Histomorphometry
(Instructors: D. Dempster and T. Wronski)
This will be a hands-on workshop primarily geared towards younger investigators who want hands-on training in the theory and implementation of histomorphometric techniques. The Workshop will run from 1:30 – 4:30 PM. It is open to anyone, at no additional charge.
Osteometrics has kindly agreed to provide the microscopes, computers and histomorphometric software to support the Workshop.
Monday PM (Evening): ASBMR/Harold M. Frost Award Presentations
Six young investigators will be selected (by a combined committee formed by the ASBMR and by the Sun Valley organizers) to present their research from the podium.
Tuesday AM: Tutorial: Analysis of Bone at the Material Level
(Chair: D. Nicolella, Southwest Research Institute, San Antonio)
- NMR measurement of bone quality (D. Nicolella, Southwest Research Institute)
- Raman spectroscopic measures of bone quality and function (M.Morris, University of Michigan)
- Probing alterations in bone structure and composition in osteoporosis using synchrotron-based imaging (L. Miller, Brookhaven National Laboratory)
- Changes in bone structure during growth and aging (S.Khosla, Mayo Clinic)
- Bone material properties are different in patients with and without fractures. (P. Hansma, University of California, Santa Barbara)
- Adolfo Diez Perez, TBA
Tuesday Evening (5:30pm - 10:00pm)
Socialize (5:30pm - 7:00pm)
Dr. Burr's Lodge Apartment
Buffet Banquet (7:00pm)
Opera House Lawn
(babysitting will be available for children ages 2-12 during the banquet)
Pepe's Piano Concert (9:00pm - 10:00pm)
Sun Valley Lodge, 2nd floor
Wednesday AM: The Interaction of Biological Factors with Mechanical Signals in Bone’s Anabolic Response
(Chair: M. Schaffler, CUNY)
- Overview of the interaction of various biological pathways with fluid shear (C. Jacobs, Columbia University)
- The interaction of the PTH receptor and mechanical signals in bone cells (J. Frangos, La Jolla Bioengineering Institute)
- Sclerostin mode of action (M. Kneissel)
- The role of sclerostin and the Wnt pathway in mediating the effects of mechanical loading (A. Robling, Indiana University)
Wednesday PM: The Translational Potential of Epigenetics in Skeletal Development
(A. van Wijnen, University of Massachussetts)
- Introduction to epigenetics and its translational potential (A. van Wijnen, University of Massachussetts)
- Runx2-dependent architectural epigenetics and control of osteoblast proliferation (A. van Wijnen, University of Massachussetts)
- Biological role of the histone deacetylase HDAC3 to skeletal development (J. Westendorf, Mayo Clinic)
- Deficiency in the methylated DNA binding protein Mecp2 and skeletal defects related to Rett syndrome (C. Schanen, Nemours Biomedical Research, Alfred DuPont Hospital for Children)